Estrogen Receptor alpha Polyclonal Antibody | E-AB-60073

Estrogen Receptor alpha Polyclonal Antibody | E-AB-60073 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1, ER alpha

Application: WB

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Epigenetics and Nuclear Signaling, Neuroscience, Signal Transduction

Background: This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined.

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant fusion protein of human Estrogen Receptor alpha (NP_000116.2).

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification Method: Affinity purification

Dilution: WB 1:1000-1:4000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 35 kDa/47 kDa/53 kDa/66 kDa

Molecular Weight(Observed): 75 kDa