Ethynylcytidine | B1266

Ethynylcytidine is a synthetic cytidine nucleoside containing a covalently bound ethynyl group with potential antineoplastic and radiosensitizing activities. Ethynylcytidine is metabolized in tumor cells to ethynylcytidine triphosphate (ECTP), which inhibits RNA synthesis by competitive inhibition of RNA polymerases I, II and III; subsequently, RNase L is activated, resulting in apoptosis.

Ethynylcytidine is a synthetic cytidine nucleoside containing a covalently bound ethynyl group with potential antineoplastic and radiosensitizing activities. Ethynylcytidine is metabolized in tumor cells to ethynylcytidine triphosphate (ECTP), which inhibits RNA synthesis by competitive inhibition of RNA polymerases I, II and III; subsequently, RNase L is activated, resulting in apoptosis.

B1266 | Ethynylcytidine DataSheet

Alternate Name/Synonyms: 1-(3-C-Ethynyl-beta-D-ribo-pentofuranosyl)cytosine; TAS-106

Appearance: Crystaline solid

Formulation: N/A

CAS Number: 180300-43-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₁H₁₃N₃O₅

Molecular Weight: 267.24

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An anticancer agent

MDL Number: N/A

PubChem CID: 176885

SMILES: C#CC1(C(OC(C1O)N2C=CC(=NC2=O)N)CO)O

InChi: InChI=1S/C11H13N3O5/c1-2-11(18)6(5-15)19-9(8(11)16)14-4-3-7(12)13-10(14)17/h1,3-4,6,8-9,15-16,18H,5H2,(H2,12,13,17)/t6-,8+,9-,11-/m1/s1

InChi Key: JFIWEPHGRUDAJN-DYUFWOLASA-N