Evans Blue Tetrasodium | 2586

Evans Blue is a potent inhibitor of the uptake of L-glutamate into synaptic vesicles. Evans blue also inhibits AMPA and kainate receptor-mediated currents with IC₅₀ values of 220 and 150 nM respectively. Also acts as a P2X-selective purinoceptor antagonist.

Evans Blue is a potent inhibitor of the uptake of L-glutamate into synaptic vesicles. Evans blue also inhibits AMPA and kainate receptor-mediated currents with IC₅₀ values of 220 and 150 nM respectively. Also acts as a P2X-selective purinoceptor antagonist.

2586 | Evans Blue Tetrasodium DataSheet

Alternate Name/Synonyms: 6,6-[(3,3'-Dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(azo)bis[4-amino- 5-hydroxy-1,3-naphthalenedisulphonic acid] tetrasodium salt

Appearance: Dark blue solid

Formulation: N/A

CAS Number: 314-13-6

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₄H₂₄N₆Na₄O₁₄S₄

Molecular Weight: 960.81

Cell-Permeable?: No

Purity: lmax: 605.0-613.0 nm (H₂O)

Solubilities: H₂O (~ 10 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A glutamate uptake inhibitor

MDL Number: MFCD00004021

PubChem CID: 24832074

SMILES: CC1=C(C=CC(=C1)C2=CC(=C(C=C2)NN=C3C=CC4=C(C3=O)C(=C(C=C4S(=O)(=O)[O-])S(=O)(=O)[O-])N)C)NN=C5C=CC6=C(C5=O)C(=C(C=C6S(=O)(=O)[O-])S(=O)(=O)[O-])N.[Na+].[Na+].[Na+].[Na+]

InChi: InChI=1S/C34H28N6O14S4.4Na/c1-15-11-17(3-7-21(15)37-39-23-9-5-19-25(55(43,44)45)13-27(57(49,50)51)31(35)29(19)33(23)41)18-4-8-22(16(2)12-18)38-40-24-10-6-20-26(56(46,47)48)14-28(58(52,53)54)32(36)30(20)34(24)42;;;;/h3-14,37-38H,35-36H2,1-2H3,(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54);;;;/q;4*+1/p-4

InChi Key: KBNIFDASRCWYGC-UHFFFAOYSA-J