EWSR1 Antibody (C-term) [APR32963G]

EWSR1 Antibody (C-term) [APR32963G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This EWSR1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 639-674 amino acids from the C-terminal region of human EWSR1.

Cellular Localisation: Nucleus. Cytoplasm. Cell membrane. Note=Relocates from cytoplasm to ribosomes upon PTK2B/FAK2 activation

Molecular Weight: 68478

Clone: Polyclonal

Gene Name: EWSR1

Gene ID: 2130

Function: Might normally function as a transcriptional repressor. EWS- fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Summary: Tissue Location: Ubiquitous.

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB, IF

Dilution: IF--1:25 WB--1:1000

Synonyms: RNA-binding protein EWS, EWS oncogene, Ewing sarcoma breakpoint region 1 protein, EWSR1, EWS