EXOSC2 polyclonal Antibody | BS71535

EXOSC2 polyclonal Antibody | BS71535 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB,IF

Application Range: WB 1:500 - 1:2000 IF 1:50 - 1:200

Background: The exosome is a multisubunit complex of 3’ to 5’ exoribonucleases. It is involved in a variety of cellular processes and is responsible for degrading unstable mRNAs that contain AU-rich elements in their untranslated 3‘ region. EXOSC2 (exosome component 2), also known as p7, RRP4 (ribosomal RNAprocessing protein 4), hRrp4p or Rrp4p, is a component of the exosome multienzyme ribonuclease complex. It contains one S1 RNA-binding domain and localizes to the cytoplasm and nucleolus. In humans, EXOSC2 is phosphorylated within the S1 RNA-binding domain at serine residue 124. This phosphorylation site is conserved from yeast to human, implying that it is of great importance in the cell. EXOSC2 is one of the four exosome subunits known to have exoribonuclease activity. It is required for the processing of the 7S pre-RNA.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: EXOSC2 polyclonal Antibody detects endogenous levels of EXOSC2 protein.

Molecular Weight: ~ 33 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: p7; RRP4; Rrp4p; hRrp4p;

Immunogen: Recombinant protein of human EXOSC2

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: