EXP-3174 | 9672

EXP-3174 is a physiologically active metabolite of losartan, produced by cytochrome P450 isoforms in the liver. EXP-3174 is a potent angiotensin II receptor, type 1 (AT1) antagonist (Kis = 0.57 and 0.67 nM for rat and human forms, respectively), producing a depressor response and vasodilatation. When administered intravenously, losartan carboxylic acid is more potent and has a longer duration of action than losartan. However, the metabolite has very low oral bioavailability.

EXP-3174 is a physiologically active metabolite of losartan, produced by cytochrome P450 isoforms in the liver. EXP-3174 is a potent angiotensin II receptor, type 1 (AT1) antagonist (Kis = 0.57 and 0.67 nM for rat and human forms, respectively), producing a depressor response and vasodilatation. When administered intravenously, losartan carboxylic acid is more potent and has a longer duration of action than losartan. However, the metabolite has very low oral bioavailability.

9672 | EXP-3174 DataSheet

Alternate Name/Synonyms: 1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-chloro-1H-imidazole-5-carboxylic acid; Losartan carboxylic acid

Appearance: Off-white solid

Formulation: N/A

CAS Number: 124750-92-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₂₁ClN₆O₂

Molecular Weight: 436.9

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A physiologically active metabolite of losartan

MDL Number: N/A

PubChem CID: 108185

SMILES: CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)C(=O)O)Cl

InChi: InChI=1S/C22H21ClN6O2/c1-2-3-8-18-24-20(23)19(22(30)31)29(18)13-14-9-11-15(12-10-14)16-6-4-5-7-17(16)21-25-27-28-26-21/h4-7,9-12H,2-3,8,13H2,1H3,(H,30,31)(H,25,26,27,28)

InChi Key: ZEUXAIYYDDCIRX-UHFFFAOYSA-N