EZCyp™ Active Human Cytochrome P450 2C19 | 7874

Cytochrome P450 2C19 (CYP2C19, EC 1.14.14.1) is a member of the cytochrome P450 monooxidase (CYP) family of microsomal xenobiotic metabolism enzymes. CYPs are membrane-bound hemeproteins responsible for Phase I biotransformation reactions, in which lipophilic drugs and other xenobiotic compounds are converted to more hydrophilic products to facilitate excretion from the body. CYP2C19 is primarily expressed in liver and intestinal tissue and catalyzes oxidation of neutral or weakly basic lipophilic molecules with 2-3 hydrogen bond donor/acceptor sites. Isoforms of the CYP2C subfamily are responsible for metabolism of nearly 20% of all small molecule drugs commonly used by humans. Polymorphisms in the human CYP2C19 gene have been implicated in clinical drug/drug interactions involving widely-prescribed drugs, including proton pump inhibitors, antiplatelet agents and anticonvulsants. ’s EZCypTM 2C19 is a permeabilized and stabilized dried yeast powder preparation containing recombinant human CYP2C19 and recombinant human P450 NADPH oxidoreductase co expressed in the same preparation.

7874 | EZCyp Active Human Cytochrome P450 2C19 DataSheet

Biomolecule/Target: EZCyp™ Active Human CYP2C19

Synonyms: Cytochrome P450 2C, Cytochrome P450 2C19, Cyt2C19, CYPIIC, CYPIIC19, Cyp2c, Microsomal cytochrome P450 2C19, active CYP2C19, human cyp2c19, human CYP2C19, CPCJ, recombinant CYP2C, P450C2C, CYPIIC17, CYPIIC19, P450IIC19

Alternates names: Vascular Endothelial Growth Factor-C, VEGFC, Flt4 ligand

Taglines: Unique, cost-effective CYP2C19 catalytic system with active recombinant human CYP2C19 coexpressed with the active NADPH reductase in a semipermeable membrane system.

NCBI Gene ID #: 7424

NCBI Gene Symbol: VEGFC

Gene Source: Human

Accession #: Q6FH59

Recombinant: Yes

Source: Pichia pastoris

Purity by SDS-PAGEs: 90%

Assay: N/A

Purity: NA

Assay #2: NA

Endotoxin Level: NA

Activity (Specifications/test method): K848, Metabolite HPLC

Biological activity: Activity of VEGF-C is tested by the stimulation of VEGF-R3 phosphorylation in cells transfected with VEGF-R3. The expected ED is > 200 ng/ml.

Results: NA

Binding Capacity: NA

Unit Definition: NA

Molecular Weight: 15-16 kDa

Concentration: N/A

Appearance: Dry powder

Physical form description: Lyophilized powder

Reconstitution Instructions: Reconstitute in 0.1% acetic acid to a concentration of 0.1-1.0 mg/ml

Amino acid sequence: N/A