EZCyp™ Active Human Cytochrome P450 2D6 | 7873

Cytochrome P450 2D6 (CYP2D6, EC 1.14.14.1) is a member of the cytochrome P450 monooxidase (CYP) family of microsomal xenobiotic metabolism enzymes. CYPs are membrane-bound hemeproteins responsible for Phase I biotransformation reactions, in which lipophilic drugs and other xenobiotic compounds are converted to more hydrophilic products to facilitate excretion from the body. CYP2D6 catalyzes oxidation of lipophilic bases with an aromatic ring and a nitrogen atom and is highly expressed in liver and brain tissue. The enzyme is responsible for metabolism of nearly 25% of all small molecule drugs commonly used by humans, particularly psychiatric drugs such as antidepressants, antipsychotics and stimulants. ’s EZCypTM 2D6 is a permeabilized and stabilized dried yeast powder preparation containing recombinant human CYP2D6 and recombinant human P450 NADPH oxidoreductase co expressed in the same preparation.

7873 | EZCyp Active Human Cytochrome P450 2D6 DataSheet

Biomolecule/Target: EZCyp™ Active Human CYP2D6

Synonyms: Cytochrome P450 2D6, Cyt2D6, CYPIID6, P450-DB1, Debrisoquine 4-hydroxylase, Active CYP2D6, human cyp2d, recombinant CYP2D6, CYP2D6, CPD6, CYP2D, CYP2DL1, P450C2D, MGC120389, MGC120390, LKM1, liver/kidney microsomal antigen 1

Alternates names: Vascular Endothelial Growth Factor-C, VEGFC, Flt4 ligand

Taglines: Unique, cost-effective CYP2D6 catalytic system with active recombinant human CYP2D6 coexpressed with the active NADPH reductase in a semipermeable membrane system.

NCBI Gene ID #: 7424

NCBI Gene Symbol: VEGFC

Gene Source: Human

Accession #: Q6FH59

Recombinant: Yes

Source: Pichia pastoris

Purity by SDS-PAGEs: 90%

Assay: N/A

Purity: NA

Assay #2: NA

Endotoxin Level: NA

Activity (Specifications/test method): K703, Metabolite HPLC

Biological activity: Activity of VEGF-C is tested by the stimulation of VEGF-R3 phosphorylation in cells transfected with VEGF-R3. The expected ED is > 200 ng/ml.

Results: NA

Binding Capacity: NA

Unit Definition: NA

Molecular Weight: 15-16 kDa

Concentration: N/A

Appearance: Dry powder

Physical form description: Lyophilized powder

Reconstitution Instructions: Reconstitute in 0.1% acetic acid to a concentration of 0.1-1.0 mg/ml

Amino acid sequence: N/A