Ezetimibe | 9468

Ezetimibe is a cholesterol transport inhibitor. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter located in the apical membrane of enterocytes. It exhibits IC50 values of 0.0005-0.05 mg/kg in various animal models, selectively blocking cholesterol absorption without inhibiting pancreatic lipolytic enzyme activities in the intestinal lumen, affecting bile acid micelle solubilization of cholesterol, or interfering with the absorption of triglycerides, fatty acids, or bile acids.

Ezetimibe is a cholesterol transport inhibitor. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter located in the apical membrane of enterocytes.

9468 | Ezetimibe DataSheet

Alternate Name/Synonyms: (3R,​4S)-​1,​4-​fluorophenyl-​3-​[(3S-​3-​4-​fluorophenyl)-​3-​hydroxypropyl]-​4-​(4-​hydroxyphenyl)-​2-​azetidinone

Appearance: White solid

Formulation: N/A

CAS Number: 163222-33-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₄H₂₁F₂NO₃

Molecular Weight: 409.43

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~15 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A a cholesterol transport inhibitor

MDL Number: MFCD00937872

PubChem CID: 150311

SMILES: C1=CC(=CC=C1C2C(C(=O)N2C3=CC=C(C=C3)F)CCC(C4=CC=C(C=C4)F)O)O

InChi: InChI=1S/C24H21F2NO3/c25-17-5-1-15(2-6-17)22(29)14-13-21-23(16-3-11-20(28)12-4-16)27(24(21)30)19-9-7-18(26)8-10-19/h1-12,21-23,28-29H,13-14H2/t21-,22+,23-/m1/s1

InChi Key: OLNTVTPDXPETLC-XPWALMASSA-N