Ezrin (phospho-T567) /Radixin (phospho-T564) /Moesin (phospho-T558) polyclonal Antibody | BS4717

Ezrin (phospho-T567) /Radixin (phospho-T564) /Moesin (phospho-T558) polyclonal Antibody | BS4717 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB

Application Range: WB: 1:500~1:1000

Background: Ezrin, Moesin and Radixin belong to a family of highly homologous Actinassociated proteins that are localized just beneath the plasma membrane. The proteins are believed to be involved in the mediation of interactions between cytoskeletal and membrane proteins. Ezrin serves as a major cytoplasmic substrate of various protein-tyrosine kinases, including the epidermal growth factor receptor. Ezrin has also been identified as a cAMP-dependent protein kinase (A-kinase) anchoring protein and designated AKAP78. Moesin and Radixin share over 70% homology with Ezrin and are coexpressed within various cell types. Despite the high degree of homology, the three proteins exhibit a distinct receptor-specific pattern of phosphorylation.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: p-Ezrin (T567) /Radixin (T564) /Moesin (T558) polyclonal Antibody detects endogenous levels of Ezrin, Radixin and Moesin only when phosphorylated at Thr567, Thr564 or Thr558, respectively.

Molecular Weight: ~ 69, 81 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Ezrin; Cytovillin; Villin-2; Villin2; Villin 2; p81; EZR; VIL2; Moesin; Membrane-organizing extension spike protein; MSN; Radixin; RDX

Immunogen: Synthetic phosphopeptide derived from human Ezrin, Radixin, Moesin respectively are around the phosphorylation site of Threonine 567, 564, 558.

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Regulation of Actin Dynamics,Tumor Angiogenesis,Contribution of ECM and Cytoskeletal Factors to EMT,G Protein-coupled Receptors Signaling to MAPK Erk,