EZSolution™ 17-AAG | 9495

A 10 mM (1 mg in 171 µl) of Hsp90 inhibitor 17-AAG (Cat. No.1774) in anhydrous DMSO.

17-AAG is a semi-synthetic derivative of Geldanamycin (Cat. No. 1564-1,5) that displays greater stability and lower in vivo toxicity compared to Geldanamycin. Binds to Heat shock protein 90 (Hsp90) (EC₅₀ = 7.2 µM) in a manner similar to geldanamycin.

9495 | EZSolution™ 17-AAG DataSheet

Alternate Name/Synonyms: Telatinib; 17-(Allylamino)-17-demethoxygeldanamycin; 17-(Allylamino)geldanamycin; Tanespimycin

Appearance: Liquid

Formulation: A 10 mM solution in DMSO

CAS Number: 75747-14-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₁H₄₃N₃O₈

Molecular Weight: 585.69

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: N/A

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A Hsp90 inhibitor

MDL Number: MFCD04973892

PubChem CID: 6505803

SMILES: CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)C)C)O)OC

InChi: InChI=1S/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-11,15-17,19,24-25,27,29,33,36H,1,12-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+/t17-,19+,24+,25+,27-,29+/m1/s1

InChi Key: AYUNIORJHRXIBJ-TXHRRWQRSA-N