EZSolution™ SB-525334 | 2881

A 10 mM (5 mg in 1456 µl) of the ALK5 inhibitor SB-525334 (Cat. No. 2880) in anhydrous DMSO.

SB-525334 is a potent and selective inhibitor of transforming growth factor-β receptor I (ALK5, TGF-βRI) (IC₅₀ = 14.3 nM); displays 4-fold less potency against ALK4 (IC₅₀ = 58.5 nM) and inactive as an inhibitor of ALK2, ALK3, and ALK6 (IC₅₀ > 10,000 nM). In cell-based assays, SB-525334 (1 µM) blocks TGF-β1-induced phosphorylation and nuclear translocation of Smad2/3 in renal proximal tubule cells and inhibits TGF-β1-induced increases in plasminogen activator inhibitor-1 (PAI-1) and procollagen α1(I) mRNA expression in A498 renal epithelial carcinoma cells.

2881 | EZSolution™ SB-525334 DataSheet

Alternate Name/Synonyms: 6-[2-(1,1-Dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline

Appearance: Liquid

Formulation: A 10 mM solution in DMSO

CAS Number: 356559-20-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₂₁N₅

Molecular Weight: 343.42

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: N/

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective ALK5 inhibitor

MDL Number: MFCD11045307

PubChem CID: 9967941

SMILES: CC1=CC=CC(=N1)C2=C(N=C(N2)C(C)(C)C)C3=CC4=NC=CN=C4C=C3

InChi: InChI=1S/C21H21N5/c1-13-6-5-7-16(24-13)19-18(25-20(26-19)21(2,3)4)14-8-9-15-17(12-14)23-11-10-22-15/h5-12H,1-4H3,(H,25,26)

InChi Key: DKPQHFZUICCZHF-UHFFFAOYSA-N