Description
Torcetrapib is a cholesteryl ester transfer protein (CETP) inhibitor (IC₅₀ = 37 nM). It raises high-density lipoprotein (HDL) cholesterol and reduces low-density lipoprotein (LDL) cholesterol levels. However, in clinical trials, Torcetrapib displayed unfavorable off-target effects in cardiovascular system. PDGFR, HGFR (c-Met), IL-2 receptor, and ErbB1- tyrosine kinase have subsequently been identified as direct off-targets of this compound.
EZSolution™ Torcetrapib is a 10 mM (5 mg in 833 µl) solution of the CETP inhibitor Torcetrapib (Cat. No. 2420) in anhydrous DMSO.
2533 | EZSolution™ Torcetrapib DataSheet
Alternate Name/Synonyms: (2R,4S)-ethyl 2-ethyl-4-(methoxycarbonyl)-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H)-carboxylate; CP-529414, CP529414, CP 529414
Appearance: Liquid
Formulation: A 10 mM solution in anhydrous DMSO
CAS Number: 262352-17-0
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₆H₂₅F₉N₂O₄
Molecular Weight: 600.47
Cell-Permeable?: Yes
Purity: ≥98%
Solubilities: N/A
Handling: Protect from light and moisture
Country of Origin: USA
Tag Line: A CETP inhibitor
MDL Number: N/A
PubChem CID: 159325
SMILES: CCC1CC(C2=C(N1C(=O)OCC)C=CC(=C2)C(F)(F)F)N(CC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)C(=O)OC
InChi: InChI=1S/C26H25F9N2O4/c1-4-18-12-21(19-11-15(24(27,28)29)6-7-20(19)37(18)23(39)41-5-2)36(22(38)40-3)13-14-8-16(25(30,31)32)10-17(9-14)26(33,34)35/h6-11,18,21H,4-5,12-13H2,1-3H3/t18-,21+/m1/s1
InChi Key: CMSGWTNRGKRWGS-NQIIRXRSSA-N
Additional Information
Storage Condition: |
-20 ̊C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
12 months |