F11 polyclonal Antibody | BS60702

F11 polyclonal Antibody | BS60702 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: Coagulation Factor XI (FXI) is a glycoprotein produced by platelets and megakaryocytes in the liver and circulates as a zymogen homodimer in plasma. Factor XI is a trypsin-like plasma serine protease that catalyzes the activation of the consolidation phase of blood coagulation through a Thrombin-generated feedback loop. The plasma half-life of Factor XI is about 52 hours, and plasma concentrations are usually 5 mg/l. During hemostasis, the coagulation protease factor (Factor XIa) activates Factor XI. Factor XI deficiency (Hemophilia C) is an injury-related bleeding disorder that leads to a variable bleeding tendency which is inherited in an autosomal recessive manner, though is not completely recessive, because heterozygotes also have a mild but definite bleeding tendency.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: F11 polyclonal Antibody detects endogenous levels of F11 protein.

Molecular Weight: ~ 70 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Coagulation factor XI; FXI; Plasma thromboplastin antecedent; PTA; F11

Immunogen: A synthetic peptide corresponding to residues in Human F11

Conjugate: N/A

Modification: N/A

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: N/A