F8A2 Antibody (N-term) [APR11889G]

F8A2 Antibody (N-term) [APR11889G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This F8A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-40 amino acids from the N-terminal region of human F8A2.

Cellular Localisation: Cytoplasm. Nucleus. Early endosome. Nucleus, nuclear body {ECO:0000250|UniProtKB:Q00558}. Note=Diffuse presence in the cytoplasm and accumulation in the nucleus (PubMed:16476778) . In absence of HTT, F8A1/F8A2/F8A3 is concentred in cytoplasm (By similarity) . Colocalized with HTT in endosomes (PubMed:16476778) . In neuron found in intranuclear structures, the intranuclear rodlets (INRs), also known as rodlets of Roncoroni, in association with ubiquitin (By similarity) {ECO:0000250|UniProtKB:Q00558, ECO:0000269|PubMed:16476778}

Molecular Weight: 39103

Clone: Polyclonal

Gene Name: F8A1

Gene ID: 474383;474384;8263

Function: RAB5A effector molecule that is involved in vesicular trafficking of early endosomes (PubMed:16476778) . Mediates the recruitment of HTT by RAB5A onto early endosomes. The HTT- F8A1/F8A2/F8A3-RAB5A complex stimulates early endosomal interaction with actin filaments and inhibits interaction with microtubules, leading to the reduction of endosome motility (PubMed:16476778) .

Summary: Tissue Location: Produced abundantly in a wide variety of cell types

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Factor VIII intron 22 protein, CpG island protein, F8A1, F8A