Factor VIIa, Human Plasma | 7687

Human factor VII is a single chain plasma glycoprotein, and is a zymogen in its native form. Proteolytic activation of factor VII, yields the enzyme factor VIIa, which when bound to the integral membrane protein tissue factor, forms an enzyme complex that proteolytically converts factor X to factor Xa. This enzyme complex is best known as the extrinsic factor Xase (pronounced ten-ase) complex, since by virtue of its tissue factor component, it is composed of protein normally extrinsic to the plasma environment. The conversion of factor VII to factor VIIa is catalyzed by a number of proteases including thrombin, factor IXa, factor Xa, factor XIa, and factor XIIa. Rapid activation also takes place when factor VII is combined with tissue factor in the presence of calcium.

7687 | Factor VIIa Human Plasma DataSheet

Biomolecule/Target: Factor VIIa

Synonyms: Proconvertin, Serum prothrombin conversion accelerator.

Alternates names: Proconvertin, Serum prothrombin conversion accelerator.

Taglines: Responsible for starting a cascade of proteolytic events that lead to thrombin generation, fibrin deposition, and platelet activation.

NCBI Gene ID #: 2247

NCBI Gene Symbol: FGF-2

Gene Source: Human

Accession #: P09038

Recombinant: No

Source: Human Plasma

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: Lot dependent

Results: Lot dependent

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 50 kDa

Concentration: N/A

Appearance: Liquid

Physical form description: In 20 mM Tris-HCl, 0.1 M NaCl pH 7.4

Reconstitution Instructions: N/A

Amino acid sequence: N/A