FADD Antibody (Center) [APR04445G]

FADD Antibody (Center) [APR04445G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This FADD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-135 amino acids from the Central region of human FADD.

Cellular Localisation: N/A

Molecular Weight: 23279

Clone: Polyclonal

Gene Name: FADD {ECO:0000303|PubMed:7538907, ECO:0000312|HGNC:HGNC:3573}

Gene ID: 8772

Function: Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors (PubMed:7538907, PubMed:23955153, PubMed:19118384, PubMed:20935634, PubMed:16762833, PubMed:24025841) . The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation (PubMed:7538907, PubMed:19118384, PubMed:20935634, PubMed:16762833) . Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis (PubMed:16762833) . Involved in interferon- mediated antiviral immune response, playing a role in the positive regulation of interferon signaling (PubMed:21109225) .

Summary: Tissue Location: Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: FAS-associated death domain protein, FAS-associating death domain-containing protein, Growth-inhibiting gene 3 protein, Mediator of receptor induced toxicity, Protein FADD, FADD, MORT1