FAK (phospho Tyr576 / Tyr577) Antibody | 79-511

FAK (phospho Tyr576 / Tyr577) Antibody | 79-511 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Homology: N/A

Immunogen: FAK (phospho-Tyr576/Tyr577) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 576/tyrosine 577 (S-T-Y (p) -Y (p) -K-A) derived from Human FAK.

Research Area: Phospho-Specific

Tested Application: WB, IF

Application: Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200

Specificiy: This antibody detects endogenous level of FAK only when phosphorylated at tyrosine 576/577.

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: 125 kDa

Validation: N/A

Isoform: N/A

Purification: Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Clonality: Polyclonal

Clone: N/A

Isotype: N/A

Conjugate: Unconjugated

Physical State: Liquid

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+) , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Concentration: 1 mg/mL

Storage Condition: Store antibody at -20˚C for up to one year.

Alternate Name: FAK, FADK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK, EIF4F, EIF4G, EIF4GI, FADK 1, PTK2

User Note: N/A

BACKGROUND: Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.