Famotidine | B3021

Famotidine is a competitive inhibitor of histamine H2-receptor located on the basolateral membrane of the parietal cells. Famotidine inhibits histamine-induced acid secretion in isolated canine parietal cells with an IC₅₀ of 0.6 µM. It suppresses histamine-induced gastric acid secretion in dogs and anesthetized rats with ID₅₀ values of 10 and 400 µg/kg, respectively. It is used to treat ulcers, gastroesophageal reflux disease and heartburn. Famotidine is also being investigated in clinical trials for treatment against COVID-19.

Famotidine is a competitive inhibitor of histamine H2-receptor located on the basolateral membrane of the parietal cells. Famotidine inhibits histamine-induced acid secretion in isolated canine parietal cells with an IC₅₀ of 0.6 µM. It suppresses histamine-induced gastric acid secretion in dogs and anesthetized rats with ID₅₀ values of 10 and 400 µg/kg, respectively. It is used to treat ulcers, gastroesophageal reflux disease and heartburn. Famotidine is also being investigated in clinical trials for treatment against COVID-19.

B3021 | Famotidine DataSheet

Alternate Name/Synonyms: 3-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfanyl]-N'-sulfamoylpropanimidamide; pepcid; N'-(Aminosulfonyl)-3-([2-(diaminomethyleneamino)-4-thiazolyl]methylthio)propanamidine; 3-(((2-((Aminoiminomethyl)amino)-4-thiazolyl)methyl)thio)-N-(aminosulfonyl)propanimidamide; (1Z)-3-[({2-[(diaminomethylidene)amino]-1,3-thiazol-4-yl}methyl)sulfanyl]-N'-sulfamoylpropanimidamide; MK-208; YM-11170

Appearance: White to Off-White Powder

Formulation:

CAS Number: 76824-35-6

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₈H₁₅N₇O₂S₃

Molecular Weight: 337.45

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: ~30 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A competitive inhibitor of histamine H2-receptor

MDL Number: MFCD00075320

PubChem CID: 5702160

SMILES: C1=C(N=C(S1)N=C(N)N)CSCCC(=NS(=O)(=O)N)N

InChi: InChI=1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)

InChi Key: XUFQPHANEAPEMJ-UHFFFAOYSA-N