Fasiglifam (TAK-875) | B1280

Fasiglifam (TAK-875) is a potent and selective agonist of GPR40 with EC₅₀ of 14 nM, 400-fold more potent than oleic acid. TAK-875 displays potent plasma glucose-lowering action and insulinotropic action during an oral glucose tolerance test in female Wistar fatty rats with impaired glucose tolerance.

Fasiglifam (TAK-875) is a potent and selective agonist of GPR40 with EC₅₀ of 14 nM, 400-fold more potent than oleic acid. TAK-875 displays potent plasma glucose-lowering action and insulinotropic action during an oral glucose tolerance test in female Wistar fatty rats with impaired glucose tolerance.

B1280 | Fasiglifam (TAK-875) DataSheet

Alternate Name/Synonyms: (S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1000413-72-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₉H₃₂O₇S

Molecular Weight: 524.63

Cell-Permeable?: Yes

Purity: ≥97% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective GPR40 agonist

MDL Number: N/A

PubChem CID: 24857286

SMILES: CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O)C)OCCCS(=O)(=O)C

InChi: InChI=1S/C29H32O7S/c1-19-12-25(34-10-5-11-37(3,32)33)13-20(2)29(19)22-7-4-6-21(14-22)17-35-24-8-9-26-23(15-28(30)31)18-36-27(26)16-24/h4,6-9,12-14,16,23H,5,10-11,15,17-18H2,1-3H3,(H,30,31)/t23-/m1/s1

InChi Key: BZCALJIHZVNMGJ-HSZRJFAPSA-N