Fbx32 polyclonal Antibody | BS90497

Fbx32 polyclonal Antibody | BS90497 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB ICC

Application Range: WB:1:500-1:1,000 ICC:1:50-1:200

Background: Muscle atrophy F-box (MAFbx) is an E3 ubiquitin ligase that initiates ATP-dependent ubiquitin-mediated proteolysis and promotes muscle atrophy. MAFbx transcript is abundant in cardiac and skeletal muscle undergoing atrophy. MAFbx -/- mice are resistant to muscle atrophy. MAFbx is thought to recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation during skeletal muscle atrophy. It interacts with MyoD by ubiquitination via a sequence found in transcriptional coactivators and therefore may play an important role in the course of muscle differentiation by determining the abundance of MyoD. MAFbx is specifically expressed in cardiac and skeletal muscle.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: Fbx32 polyclonal Antibody detects endogenous levels of Fbx32 protein.

Molecular Weight: 41 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: MAFbx, FBXO32, 4833442G10Rik, AI430017, Atrogin 1, Atrogin-1, ATROGIN1, Atrophy gene 1, F box only protein 32, F-box only protein 32, F-box protein 32, FBX32, fbxo25, FBXO32, FLJ32424, MAFbx, MGC108443, MGC137646, MGC33610, Muscle atrophy F box, Muscle atrophy F box protein, Muscle atrophy F-box protein,

Immunogen: Recombinant protein corresponding to human Fbx32 1-200aa.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: