FBXL17 Isoform 2 Antibody (C-term) [APR04628G]

FBXL17 Isoform 2 Antibody (C-term) [APR04628G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This FBXL17 Isoform 2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 262-297 amino acids from the C-terminal region of human FBXL17 Isoform 2.

Cellular Localisation: Cytoplasm. Nucleus Note=Present in the cytoplasm and nucleus; more abundant in the cytoplasm.

Molecular Weight: 75695

Clone: Polyclonal

Gene Name: FBXL17 {ECO:0000303|PubMed:24035498, ECO:0000312|HGNC:HGNC:13615}

Gene ID: 64839

Function: Substrate-recognition component of the SCF (FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC) (PubMed:30190310) . FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF (FBXL17) complex and degraded by the proteaseome (PubMed:30190310) . The ability of the SCF (FBXL17) complex to eliminate compromised BTB dimers is required for the differentiation and survival of neural crest and neuronal cells (By similarity) . The SCF (FBXL17) complex mediates ubiquitination and degradation of BACH1 (PubMed:24035498, PubMed:30190310) . The SCF (FBXL17) complex is also involved in the regulation of the hedgehog/smoothened (Hh) signaling pathway by mediating the ubiquitination and degradation of SUFU, allowing the release of GLI1 from SUFU for proper Hh signal transduction (PubMed:27234298) . The SCF (FBXL17) complex mediates ubiquitination and degradation of PRMT1 (By similarity) .

Summary: N/A

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB, FC, IHC-P

Dilution: FC--1:25 IHC-P--1:100~500 WB--1:1000

Synonyms: F-box/LRR-repeat protein 17, F-box and leucine-rich repeat protein 17, F-box only protein 13, FBXL17, FBL17, FBX13, FBXO13