FBXO3 Antibody (C-term) [APR32669G]

FBXO3 Antibody (C-term) [APR32669G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This FBXO3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 395-422 amino acids from the C-terminal region of human FBXO3.

Cellular Localisation: Nucleus. Note=Colocalizes with PML at the peripheries of nuclear bodies

Molecular Weight: 54561

Clone: Polyclonal

Gene Name: FBXO3

Gene ID: 26273

Function: Substrate recognition component of the SCF (SKP1-CUL1-F-box protein) -type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation.

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, FC

Dilution: WB--1:1000 FC--1:10~50

Synonyms: F-box only protein 3, FBXO3, FBX3