FCGR3A polyclonal Antibody | BS7381

FCGR3A polyclonal Antibody | BS7381 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB 1:500 - 1:2000

Background: This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-Antibody complexes from the circulation, as well as other other Antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: FCGR3A polyclonal Antibody detects endogenous levels of FCGR3A protein.

Molecular Weight: ~ 50 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: CD 16; CD 16a; CD16; CD16a; CD16a antigen; CD16B; CD16b antigen; Fc fragment of IgG; Fc fragment of IgG low affinity IIIa receptor (CD16) ; Fc fragment of IgG, low affinity III, receptor (CD16) ; Fc fragment of IgG, low affinity III, receptor for (CD16) ; Fc fragment of IgG, low affinity IIIa, receptor (CD16) ; Fc fragment of IgG, low affinity IIIa, receptor (CD16a) ; Fc fragment of IgG, low affinity IIIb, receptor (CD16b) ; Fc fragment of IgG, low affinity IIIb, receptor for (CD16) ; Fc gamma R3; Fc gamma receptor III 2 (CD 16) ; Fc gamma receptor III A; Fc gamma receptor IIIA; Fc gamma receptor IIIb (CD 16) ; Fc gamma RIII alpha; Fc gamma RIII; Fc gamma RIII beta; Fc gamma RIIIa; Fc gamma RIIIb; Fc of IgG; Fc-gamma receptor III2 (CD 16) ; Fc-gamma receptor III2 (CD16) ; Fc-gamma receptor IIIb (CD16) ; Fc-gamma RIII; Fc-gamma RIII-alpha; Fc-gamma RIIIa; FCG 3; FCG3; FCG3A_HUMAN; FCgammaRIIIA; FCGR 3; FCGR 3A; FCGR3; FCGR3A; FCGR3A protein; FCGRIII; FCGRIII-2; FcR 10; FcR-10; FcR10; FcRIII; FcRIIIa; IGFR 3; IGFR3; IgG Fc receptor III 1; IgG Fc receptor III 2; IgG Fc receptor III-2; immunoglobulin G Fc receptor III; immunoglobulin G Fc receptor III-2; Low affinity IIIa receptor; Low affinity immunoglobulin gamma Fc region receptor III A; Low affinity immunoglobulin gamma Fc region receptor III-A; Low affinity immunoglobulin gamma Fc region receptor IIIB; neutrophil-specific antigen NA;

Immunogen: Recombinant full length Human FCGR3A.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Regulation of Apoptosis,Mitochondrial Control of Apoptosis,