Ferrostatin-1 | 2230

Cell-permeable. A potent ferroptosis (an iron-dependent form of non-apoptotic cell death) inhibitor. Inhibits erastin-induced ferroptosis in HT-1080 cells with an EC₅₀ of 60 nM. Ferrostatin-1 inhibits ferroptosis in cancer cells as well as blocks glutamate-induced cell death in organotypic rat brain slices.

Ferrostatin-1 is a potent ferroptosis (an iron-dependent form of non-apoptotic cell death) inhibitor. Inhibits erastin-induced ferroptosis in HT-1080 cells with an EC₅₀ of 60 nM.

2230 | Ferrostatin-1 DataSheet

Alternate Name/Synonyms: Fer-1; Ethyl 3-amino-4-(cyclohexylamino)benzoate

Appearance: Off-white solid

Formulation: N/A

CAS Number: 347174-05-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₅H₂₂N₂O₂

Molecular Weight: 262.35

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: DMSO (100 mM)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A ferroptosis inhibitor.

MDL Number: MFCD08072959

PubChem CID: 4068248

SMILES: CCOC(=O)C1=CC(=C(C=C1)NC2CCCCC2)N

InChi: InChI=1S/C15H22N2O2/c1-2-19-15(18)11-8-9-14(13(16)10-11)17-12-6-4-3-5-7-12/h8-10,12,17H,2-7,16H2,1H3

InChi Key: UJHBVMHOBZBWMX-UHFFFAOYSA-N