FGF-2/FGF-basic, Bovine Pituitary | P1590

FGF-basic is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from AUG and non-AUG (CUG) initiation codons resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. there are differences in the tissue distribution and concentration of these 2 growth factors.

P1590 | FGF-2/FGF-basic, Bovine Pituitary DataSheet

Biomolecule/Target :

Synonyms: FGF2, HBGF-2, Prostatropin, Basic fibroblast growth factor, Heparin-binding growth factor 2

Alternates names: FGF2, HBGF-2, Prostatropin, Basic fibroblast growth factor, Heparin-binding growth factor 2

Taglines: A growth factor involved in angiogenesis, wound healing and embryonic development

NCBI Gene ID #: 281161

NCBI Gene Symbol: FGF-2

Gene Source: Bovine

Accession #: P03969

Recombinant: FALSE

Source: Bovine Pituitary.

Purity by SDS-PAGE: 0.95

Assay: SDS-PAGE

Purity:

Assay #2:

Endotoxin Level:

Activity (Specifications/test method): The recommended concentration in responsive cells is 0.1 to 2 ng/ml.

Biological activity:

Results:

Binding Capacity:

Unit Definition:

Molecular Weight: 16 kDa

Concentration:

Appearance: Lyophilized

Physical form description: Lyophilized from a concentrated sterile solution containing 50mM Na2HPO4, pH-7.5 & 0.5% HSA.

Reconstitution Instructions: It is recommended to reconstitute the lyophilized FGF-2 Bovine in sterile 18M-cm H2O not less than 100ug/ml, which can then be further diluted to other aqueous solutions.

Amino acid sequence:

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans