FH535 | 2657

FH535 is a potent, reversible dual inhibitor of Wnt/β-catenin and a PPARγ and PPARδ signaling. FH535 antagonizes both PPARg and PPARδ ligand-dependent activation and shows structural similarity to GW9662, a known PPARgamma antagonist. The compound is selectively toxic to some carcinomas expressing the Wnt/β-catenin pathway.

FH535 is a potent, reversible dual inhibitor of Wnt/β-catenin and a PPARγ and PPARδ signaling. FH535 antagonizes both PPARg and PPARδ ligand-dependent activation and shows structural similarity to GW9662, a known PPARgamma antagonist.

2657 | FH535 DataSheet

Alternate Name/Synonyms: 2,5-Dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide

Appearance: Off-white solid

Formulation: N/A

CAS Number: 108409-83-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₃H₁₀Cl₂N₂O₄S

Molecular Weight: 361.2

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~25 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A Wnt pathway antagonist

MDL Number: MFCD01212888

PubChem CID: 3463933

SMILES: CC1=C(C=CC(=C1)[N+](=O)[O-])NS(=O)(=O)C2=C(C=CC(=C2)Cl)Cl

InChi: InChI=1S/C13H10Cl2N2O4S/c1-8-6-10(17(18)19)3-5-12(8)16-22(20,21)13-7-9(14)2-4-11(13)15/h2-7,16H,1H3

InChi Key: AXNUEXXEQGQWPA-UHFFFAOYSA-N