Fibrinogen | unconjugated antibody | AS10 1337

Fibrinogen | unconjugated antibody | AS10 1337 | Gentaur UK, US & Europe Distribution

Immunogen: human fibrinogen CAA50740

Host: Goat

Conjugation: N/A

Clonality: Polyclonal

Isotype: N/A

Purity: Immunogen affinity purified using solid phase human Fibrinogen.

Format: Liquid

Tested Application: Immunoassays

Related Products: IMS06-038-312 | Anti-Fibrinogen | biotinylated antibody, chicken antibodiesIMS09-038-335 | Anti-Fibrinogen | labelled with fluorescein, chicken antibodies

Recommended Dilutions: The optimal working dilution should be determined by the investigator

Molecular weight: 24 kDa

Confirmed Reactivity: Human fibrinogen

Predicted Reactivity: Chicken, Mouse

Not reactive in: No confirmed exceptions from predicted reactivity are currently known

Additional Information: Affinity purified using solid phase human fibrinogen.Antibody is supplied in 10 mM sodium phosphate, 0.15 M sodium chloride, pH 7.2. Contains 0.05% (w/v) sodium azide as preservative. Antibody purity is > 95% based on SDS-PAGE.

Background: Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N-terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/ml. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel et al. 2000; Rapold et al. 1989) .

Reconstitution: N/A

Storage: Store at -20º C.

TAIR Nnumbre: N/A

Category: Cardiovascular

Research Area: Proteomics