FIGLA Antibody (Center) [APR04274G]

FIGLA Antibody (Center) [APR04274G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This FIGLA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 108-137 amino acids from the Central region of human FIGLA.

Cellular Localisation: Nucleus.

Molecular Weight: 24123

Clone: Polyclonal

Gene Name: FIGLA

Gene ID: 344018

Function: Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E-box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters.

Summary: Tissue Location: Germ cells. Expressed in the fetal ovary, but not by a range of other tissues. Expression increases across mid-gestation, rising some 40-fold by the time of primordial follicle formation

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Factor in the germline alpha, FIGalpha, Class C basic helix-loop-helix protein 8, bHLHc8, Folliculogenesis-specific basic helix-loop-helix protein, Transcription factor FIGa, FIGLA, BHLHC8