FK228 | 2447

A natural prodrug that inhibits Class I histone deacetylases (HDACs) (IC₅₀ values are: 36, 47, 510 and 14000 nM for HDAC1, HDAC2, HDAC4 and HDAC6, respectively). Displays potent anticancer activities.

FK228 is a natural prodrug that inhibits Class I histone deacetylases (HDACs) (IC₅₀ values are: 36, 47, 510 and 14000 nM for HDAC1, HDAC2, HDAC4 and HDAC6, respectively).

2447 | FK228 DataSheet

Alternate Name/Synonyms: Romidepsin; Depsipeptide; FR901228

Appearance: White solid

Formulation: N/A

CAS Number: 128517-07-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₃₆N₄O₆S₂

Molecular Weight: 540.7

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~ 5 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A potent Class I HDAC inhibitor.

MDL Number: N/A

PubChem CID: 5352062

SMILES: CC=C1C(=O)NC(C(=O)OC2CC(=O)NC(C(=O)NC(CSSCCC=C2)C(=O)N1)C(C)C)C(C)C

InChi: InChI=1S/C24H36N4O6S2/c1-6-16-21(30)28-20(14(4)5)24(33)34-15-9-7-8-10-35-36-12-17(22(31)25-16)26-23(32)19(13(2)3)27-18(29)11-15/h6-7,9,13-15,17,19-20H,8,10-12H2,1-5H3,(H,25,31)(H,26,32)(H,27,29)(H,28,30)/b9-7+,16-6-/t15-,17-,19-,20+/m1/s1

InChi Key: OHRURASPPZQGQM-GCCNXGTGSA-N