Flavopiridol | 2090

Cell-permeable. Flavopiridol is a synthetic flavonoid compound used as an anticancer agent. It is a serine/threonine kinase inhibitor that broadly targets cyclin-dependent kinases (CDKs), including the cyclin 9/cyclin T complex (pTEF-b), preventing activation of RNA polymerase II. Flavopiridol initiates cell cycle arrest and p53-independent apoptosis through down-regulation of Mcl-1 and X-linked inactivator of apoptosis (XIAP).

Flavopiridol is a synthetic flavonoid compound used as an anticancer agent. It is a serine/threonine kinase inhibitor that broadly targets cyclin-dependent kinases (CDKs), including the cyclin 9/cyclin T complex (pTEF-b), preventing activation of RNA polymerase II. Flavopiridol initiates cell cycle arrest and p53-independent apoptosis through down-regulation of Mcl-1 and X-linked inactivator of apoptosis (XIAP).

2090 | Flavopiridol DataSheet

Alternate Name/Synonyms: 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4-chromenone; HMR 1275; L86-8275; NSC 649890

Appearance: Yellow solid

Formulation: N/A

CAS Number: 146426-40-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₁H₂₀ClNO₅

Molecular Weight: 401.84

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~15 mg/ml ) or Ethanol (~ 8 mg/ml)

Handling: Protect from light

Country of Origin: USA

Tag Line: A potent CDK inhibitor

MDL Number: MFCD00894265

PubChem CID: 5287969

SMILES: CN1CCC(C(C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O

InChi: InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26) 9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2, 1H3/t12-,17+/m0/s1

InChi Key: BIIVYFLTOXDAOV-YVEFUNNKSA-N