FLI-06 | 2603

A potent Notch signaling (EC₅₀ = 2.3 µM) as well as the early secretory pathway inhibitor. FLI-06 leads to a disruption of the Golgi by a mechanism different from Brefeldin A (Cat. No. 1560) or other known secretion inhibitors. FLI-06 blocks secretion by inhibiting the recruitment of cargo to ER exit sites, but not the formation of COPII vesicles. FLI-06 transforms the tubular regions of the ER to large sheets, suggesting that regions of high curvature at ER exit sites are essential for the recruitment of cargo.

FLI-06 is a potent Notch signaling (EC₅₀ = 2.3 µM) as well as the early secretory pathway inhibitor. FLI-06 leads to a disruption of the Golgi by a mechanism different from Brefeldin A (Cat. No. 1560) or other known secretion inhibitors. FLI-06 blocks secretion by inhibiting the recruitment of cargo to ER exit sites, but not the formation of COPII vesicles.

2603 | FLI-06 DataSheet

Alternate Name/Synonyms: Cyclohexyl 1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylate

Appearance: Yellow solid

Formulation: N/A

CAS Number: 313967-18-9

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₃₀N₂O₅

Molecular Weight: 438.52

Cell-Permeable?: Yes

Purity: >98% by HPLC

Solubilities: DMSO (~40 mg/ml) or EtOH (~ 8 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent Notch signaling inhibitor

MDL Number: N/A

PubChem CID: 3103157

SMILES: CC1(C)CC(C(C(C2=CC=C([N+]([O-])=O)C=C2)C(C(OC3CCCCC3)=O)=C(C)N4)=C4C1)=O

InChi: InChI=1S/C25H30N2O5/c1-15-21(24(29)32-18-7-5-4-6-8-18)22(16-9-11-17(12-10-16)27(30)31)23-19(26-15)13-25(2,3)14-20(23)28/h9-12,18,22,26H,4-8,13-14H2,1-3H3

InChi Key: SWWVFYHSSOWZMF-UHFFFAOYSA-N