FLT1, human recombinant | 4951

The flt-1 gene was first described in 1990. The receptor contains seven immunoglobulin-like extracellular domains, a single transmembrane region and an intracellular split tyrosine kinase domain. Compared to VEGFR-2 the Flt-1 receptor has a higher affinity for VEGF but a weaker signaling activity. VEGFR-1 thus leads not to proliferation of endothelial cells, but mediates signals for differentiation. Soluble FLT1 Human Recombinant produced in baculovirus is monomeric, glycosylated, polypeptide containing 688 amino acids and having a molecular mass of 96 kDa. The soluble receptor protein contains only the first 6 extracellular domains, which contain all the information necessary for binding of VEGF. The FLT1 is purified by proprietary chromatographic techniques.

4951 | FLT1 human recombinant DataSheet

Biomolecule/Target: N/A

Synonyms: Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, Vascular permeability factor receptor

Alternates names: Gremlin-2, Cysteine knot superfamily 1, BMP antagonist 2, Protein related to DAN and cerberus, DAN domain family member 3

Taglines: Controls cell proliferation and differentiation

NCBI Gene ID #: 64388

NCBI Gene Symbol: GREM2

Gene Source: Human

Accession #: Q9H772

Recombinant: Yes

Source: Insect cells

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: 90%

Assay #2: HPLC

Endotoxin Level: <0.1 ng/g

Activity (Specifications/test method): N/A

Biological activity: Test in process

Results: 8-500 ng/ml.

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 17.2 kDa

Concentration: N/A

Appearance: Lyophilized protein

Physical form description: Lyophilized from sterile-filtered solution containing PBS

Reconstitution Instructions: Reconstitute to 1 mg/ml with sterilized dHO. Pipette to dissolve the protein pellet completely

Amino acid sequence: N/A