Flt3-L (H206) polyclonal Antibody | BS2280

Flt3-L (H206) polyclonal Antibody | BS2280 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200

Background: Flt 3 ligand (Flt 3-L), variously designated Flt 3/Flk 2 ligand or FL, is a 17 kDa hematopoietic growth factor that stimulates the proliferation of stem and CD34+ progenitor cells and has been cloned from both mouse and human genomes. Flt 3-L is a potent in vitro growth stimulator of granulocytemacrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and G-CSF-dependent granulocyte-macrophage committed precursors from Lin CD34+ bone marrow cells as well as other primitive B cell populations. Additionally, Flt 3-L stimulates the proliferation of hematopoietic progenitor cells isolated from mouse fetal liver or adult mouse bone marrow. Flt 3-L does not, however, affect the growth of erythroid-committed progenitors. A Flt-3 ligand exists in two forms and is active as both a soluble and as a membrane-bound ligand. The Flt 3-L receptor, Flt 3, is a tyrosine kinase expressed on CD34+ cells that shares a high degree of homology with the SCF (stem cell factor) receptor, c-Kit and c-Fms.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Flt3-L (H206) polyclonal Antibody detects endogenous levels of Flt3-L protein.

Molecular Weight: ~ 26 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Fms-related tyrosine kinase 3 ligand; Flt3 ligand; Flt3L; SL cytokine; FLT3LG

Immunogen: Synthetic peptide, corresponding to amino acids 180-230 of Human Flt3-L.

Conjugate: N/A

Modification: N/A

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: N/A