FNDC5, human/mouse recombinant | 7574

Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure.

7574 | FNDC5 human/mouse recombinant DataSheet

Biomolecule/Target: FNDC5

Synonyms: Fibronectin Type III Domain-containing Protein 5; Fibronectin Type III Repeat-containing Protein 2

Alternates names: Fibronectin Type III Domain-containing Protein 5; Fibronectin Type III Repeat-containing Protein 2

Taglines: Improves systemic metabolism by increasing energy expenditure.

NCBI Gene ID #: 2252

NCBI Gene Symbol: HBGF-7

Gene Source: Human/Mouse

Accession #: P21781

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: <0.1 EU/g by LAL method

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: ~16.0 kDa. (extracellular domain, human (aa 32-152) / mouse (aa 29-149)) is untagged. FNDC5 extracellular domain has 100% identity between human, mouse and rat.

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized in PBS.

Reconstitution Instructions: Reconstitute with 100 l sterile distilled water.

Amino acid sequence: N/A