Fostamatinib Disodium | 1936

A potent, ATP-competitive and selective Syk (Spleen tyrosine kinase) inhibitor (IC₅₀ = 41 nM). Inhibits tumor growth in the Eμ- TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling.

Fostamatinib Disodium is a potent, ATP-competitive and selective Syk (Spleen tyrosine kinase) inhibitor (IC₅₀ = 41 nM). Inhibits tumor growth in the Eμ- TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling.

1936 | Fostamatinib Disodium DataSheet

Alternate Name/Synonyms: (6-((5-Fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-3-oxo-2H-pyrido[3,2-b][1,4]oxazin-4(3H)-yl)methyl dihydrogen phosphate, disodium

Appearance: Off-white solid

Formulation: N/A

CAS Number: 1025687-58-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₂₄FN₆O₉PNa₂

Molecular Weight: 624.42

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent, ATP-competitive and selective Syk inhibitor

MDL Number: MFCD16628163

PubChem CID: 25008120

SMILES: CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP (=O)([O-])[O-])C.[Na+].[Na+]

InChi: InChI=1S/C23H26FN6O9P.2Na/c1-23(2)21(31)30(11-38-40(32, 33)34)20-14(39-23)6-7-17(28-20)27-19-13(24)10-25-22(29-19)26-12-8-15(35- 3)18(37-5)16(9-12)36-4;;/h6-10H,11H2,1-5H3,(H2,32,33,34)(H2,25,26,27,28, 29);;/q;2*+1/p-2

InChi Key: HSYBQXDGYCYSGA-UHFFFAOYSA-L