FOXA2 polyclonal Antibody | BS90526

FOXA2 polyclonal Antibody | BS90526 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB ICC/IF

Application Range: WB:1:1,000-1:5,000 ICC:1:50-1:200

Background: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity) . In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally discribed as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: FOXA2 polyclonal Antibody detects endogenous levels of FOXA2 protein.

Molecular Weight: 52 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: HNF-3-beta, HNF-3B, TCF-3B, FOXA2, Forkhead box A2, Forkhead box protein A2, FOX A2, foxa2, FOXA2, Hepatic nuclear factor 3 beta, Hepatocyte nuclear factor 3, Hepatocyte nuclear factor 3 beta, Hepatocyte nuclear factor 3-beta, HNF 3B, HNF-3-beta, HNF-3B, HNF3B, MGC19807, TCF 3B, TCF-3B, TCF3B, Transcription factor 3B,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: