FoxJ1 (T295) polyclonal Antibody | BS2116

FoxJ1 (T295) polyclonal Antibody | BS2116 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200

Background: Forkhead-box J1 (FOXJ1) is a 421-amino acid transcription factor that suppresses T cell activity and thus spontaneous autoimmunity, through the repression of NF˚B activity. FOXJ1 also inhibits the humoral immune response in B cells; FOXJ1 deficiency in B cells results in spontaneous and accentuated germinal center formation, implicated in the development of pathogenic autoantibodies and accentuated responses to immunizations. Abnormal expression of FOXJ1 may be associated with autoimmune diseases and/or other inflammatory diseases. FOXJ1 is also required for cilia formation and left-right axis determination because it increases calpastatin expression, a protein necessary for the ability of basal bodies to anchor to the apical cytoskeleton. FOXJ1 expression may function as an early marker of epithelial cell differentiation, recovery, and function.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: FoxJ1 (T295) polyclonal Antibody detects endogenous levels of FoxJ1 protein.

Molecular Weight: ~ 45 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Forkhead box protein J1; Forkhead-related protein FKHL13; Hepatocyte nuclear factor 3 forkhead homolog 4; HFH-4; FOXJ1; FKHL13; HFH4

Immunogen: Synthetic peptide, corresponding to amino acids 264-315 of Human FoxJ1.

Conjugate: N/A

Modification: N/A

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: N/A