FSH concentration test in Urine | FSH 141

INTENDED USE:

One Step Midstream Style FSH Urine Test is a test kit for the determination of FSH (human Follicular Stimulating Hormone) concentration in urine specimens. Test results are read visually without any instrument.

SUMMARY AND EXPLANATION:

Follicle-stimulating hormone is a glycoprotein hormone weighing approximately 30,000 Da. It is composed of two polypeptide chains: the alpha and beta subunits. In response to Gonadotropin- releasing hormone (GnRH) produced by the hypothalamus, the basophilic cells of the anterior pituitary secrete FSH and Luteinizing Hormone (LH). Both these hormones control gonadal development and maintenance. FSH controls the development of the ovarian follicles in females and spermatogenesis in males. Both LH and FSH act in a negative feedback effect on the hypothalamus, thus regulating the circulatory levels of both hormones. As a woman nears perimenopause, the number of small antral follicles recruited in each cycle diminishes and consequently insufficient Inhibin B is produced to fully lower FSH and the serum level of FSH begins to rise. The most common reason for high serum FSH concentration is in a female who is undergoing or has recently undergone menopause. High levels of FSH indicate that the normal restricting feedback from the gonad is absent, leading to an unrestricted pituitary FSH production. If high FSH levels occur during the reproductive years, it is abnormal. Conditions with high FSH levels include: Premature menopause also known as Premature Ovarian Failure, Poor ovarian reserve also known as Premature Ovarian Aging, Gonadal dysgenesis, Turner syndrome Castration, Testicular failure, Klinefelter syndrome, etc. Most of these conditions are associated with subfertility and/or infertility.