FUK polyclonal Antibody | BS61575

FUK polyclonal Antibody | BS61575 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: Blood group antigen recognition, metastasis and inflammation utilize fucose, a sugar found in glycoproteins and glycolipids. Fucokinase, also designated L-fucose kinase or FUK, is a 1,084 amino acid enzyme that plays a role in the salvage pathway of fucose reutilization. A member of the GHMP kinase family, Fucokinase exists as two alternative splice variants and catalyzes L-fucose phosphorylation to form beta-L-fucose 1-phosphate. The gene encoding Fucokinase maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: FUK polyclonal Antibody detects endogenous levels of FUK protein.

Molecular Weight: ~ 117 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: L-fucose kinase; Fucokinase; FUK

Immunogen: Synthetic peptide, corresponding to amino acids 9-53 of Human FUK.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: