FUS/TLS polyclonal Antibody | BS90542

FUS/TLS polyclonal Antibody | BS90542 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB ICC/IF IHC FC

Application Range: WB:1:1,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Background: EWS and FUS/TLS are nuclear RNA-binding proteins. As a result of chromosome translocation, the EWS gene is fused to a variety of transcription factors, including ATF-1, in human neoplasias. In the Ewing family of tumors, the N-terminal domain of EWS is fused to the DNA-binding domain of various Ets transcription factors, including Fli-1, ETV1 and FEV. The EWS/Fli-1 chimeric protein acts as a more potent transcriptional activator than Fli-1 and can promote cell transformation. In human myxoid liposarcomas and myeloid leukemias, chromosomal translocation results in the fusion of the N-terminal region of FUS/TLS with the open reading frame of CHOP. In normal cells, FUS/TLS binds to the DNA-binding domains of nuclear steroid receptors and is also present in subpopulations of TFIID complexes, indicating a potential role for FUS/TLS in the processing of primary transcripts that are generated in response to hormone-induced transcription.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: FUS/TLS polyclonal Antibody detects endogenous levels of FUS/TLS protein.

Molecular Weight: 75 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: FUS, 75 kDa DNA pairing protein, 75 kDa DNA-pairing protein, ALS6, Amyotrophic lateral sclerosis 6, fus, FUS CHOP, Fus like protein, FUS, FUS1, Fused in sarcoma, Fusion (involved in t (12;16) in malignant liposarcoma), Fusion derived from t (12;16) malignant liposarcoma, Fusion gene in myxoid liposarcoma, Heterogeneous nuclear ribonucleoprotein P2, hnRNP P2, hnRNPP2, Oncogene FUS, Oncogene TLS, POMp75, RNA binding protein FUS, RNA-binding protein FUS, TLS, TLS CHOP, Translocated in liposarcoma, Translocated in liposarcoma protein,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: