Fusion glycoprotein F0 polyclonal Antibody | BS90544

Fusion glycoprotein F0 polyclonal Antibody | BS90544 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Avian avulavirus 1

Application: WB ELISA

Application Range: WB:1:500-1,000 ELISA:1:5,000-1:10,000

Background: During virus entry, induces fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. The fusogenic activity is inactive untill entry into host cell endosome, where a furin-like protease cleaves off a small peptide between F1 and F2. Interacts directly with heparan sulfate and may participate in virus attachment. Furthermore, the F2 subunit was identifed as the major determinant of RSV host cell specificity. Later in infection, proteins F expressed at the plasma membrane of infected cells can mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis. The fusion protein is also able to trigger p53-dependent apoptosis.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: Fusion glycoprotein F0 polyclonal Antibody detects endogenous levels of Fusion glycoprotein F0 protein.

Molecular Weight: 59 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: F, Fusion glycoprotein F0, Fusion glycoprotein F1, Fusion glycoprotein F2, Fusion protein (F), RSV fusion protein,

Immunogen: Synthetic peptide corresponding to Avian avulavirus 1 Fusion glycoprotein F0 aa 540-554.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Peptide affinity purified.

Pathway: