FZD1 Antibody (C-term) [APR31987G]

FZD1 Antibody (C-term) [APR31987G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This FZD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 504-533 amino acids from the C-terminal region of human FZD1.

Cellular Localisation: Cell membrane; Multi-pass membrane protein

Molecular Weight: 71158

Clone: Polyclonal

Gene Name: FZD1

Gene ID: 8321

Function: Receptor for Wnt proteins (PubMed:10557084) . Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B (PubMed:10557084) . Contradictory results showing activation by WNT7B have been described for mouse (By similarity) . Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:10557084) . The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:10557084) . A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable) .

Summary: Tissue Location: Expressed in adult heart, placenta, lung, kidney, pancreas, prostate, and ovary and in fetal lung and kidney

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Frizzled-1, Fz-1, hFz1, FzE1, FZD1