G418 Sulfate | 1557

Aminoglycoside antibiotic related to gentamycin that inhibits prokaryotic and eukaryotic protein synthesis. Toxic to bacteria, yeast, protozoans, helminths, higher plant, and mammalian cells. Widely used in the selection of eukaryotic expression vectors carrying the bacterial neor/kanr genes. The product of these genes, aminoglycoside 3′-phosphotransferase, inactivates G418, neomycin, and kanamycin by phosphorylation. Introduction of either of these genes into cells can confer resistance to G418, which enables cells to grow in media containing G418.

G418 sulfate is an aminoglycoside antibiotic related to gentamycin that inhibits prokaryotic and eukaryotic protein synthesis. Toxic to bacteria, yeast, protozoans, helminths, higher plant, and mammalian cells. Widely used in the selection of eukaryotic expression vectors carrying the bacterial neor/kanr genes.

1557 | G418 Sulfate DataSheet

Alternate Name/Synonyms: Antibiotic G418, G418

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 108321-42-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: Yes

Molecular Formula: C₂₀H₄₀N₄O₁₀. 2 H₂SO₄

Molecular Weight: 692.71

Cell-Permeable?: No

Purity: >720 U/mg (potency)

Solubilities: H₂O (50 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: An antibiotic and a selection agent

MDL Number: MFCD00058314

PubChem CID: 16760463

SMILES: CC(C1C(C(C(C(O1)OC2C(CC(C(C2O)OC3C(C(C(CO3)(C)O)NC)O)N)N)N)O)O)O.OS(=O)(=O)O.OS(=O)(=O)O

InChi: InChI=1S/C20H40N4O10.2H2O4S/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19;2*1-5(2,3)4/h6-19,24-30H,4-5,21-23H2,1-3H3;2*(H2,1,2,3,4)

InChi Key: UHEPSJJJMTWUCP-UHFFFAOYSA-N