GABRA1 Antibody (C-term) [APG03313G]

GABRA1 Antibody (C-term) [APG03313G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M

Specificity: This GABRA1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 405-438 amino acids from the C-terminal region of human GABRA1.

Cellular Localisation: Cell junction, synapse, postsynaptic cell membrane {ECO:0000250|UniProtKB:P08219}; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P62813}

Molecular Weight: 51802

Clone: Polyclonal

Gene Name: GABRA1

Gene ID: 2554

Function: Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:23909897, PubMed:25489750, PubMed:29950725) . Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:23909897, PubMed:25489750) . The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity) . The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity (PubMed:23909897, PubMed:25489750) . GABRA1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection (By similarity) . Functions also as histamine receptor and mediates cellular responses to histamine (By similarity) .

Summary: N/A

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Gamma-aminobutyric acid receptor subunit alpha-1, GABA (A) receptor subunit alpha-1, GABRA1