GAD1 Antibody | 18-876

GAD1 Antibody | 18-876 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human GAD1 (NP_000808.2) .

Research Area: Immunology, Neuroscience, Signal Transduction

Tested Application: WB

Application: WB: 1:500 - 1:2000

Specificiy: N/A

Positive Control 1: SKOV3

Positive Control 2: Jurkat

Positive Control 3: Mouse pancreas

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Observed: 67kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: GAD1, SCP, OTTHUMP00000204995, OTTHUMP00000204994, OTTHUMP00000204993, OTTHUMP00000204990, glutamate decarboxylase 67 kDa isoform, glutamate decarboxylase 1 (brain, 67kDa) , glutamate decarboxylase 1, GAD-67, GAD, FLJ45882, 67 kDa glutamic acid decarboxylase, GAD67

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.