GAD1, human recombinant | P1153

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This protein may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Recombinant human GAD1 protein, fused to His-tag at N-terminus, was expressed in E.coli.

P1153 | GAD1 human recombinant DataSheet

Biomolecule/Target: GAD1

Synonyms: CPSQ1, GAD, SCP, Glutamate decarboxylase 1

Alternates names: Mammotropin, Luterotropic hormone, Lutetropin, Prlr, PRL, luteotropic hormone, LTH, PRLR, PRL-R, PRL R

Taglines: Catalyzes the production of GABA

NCBI Gene ID #: 5617

NCBI Gene Symbol: PRL

Gene Source: Human

Accession #: P01236

Recombinant: Yes

Source: E.coli

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 23.3 kDa

Concentration: N/A

Appearance: Liquid

Physical form description: In 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

Reconstitution Instructions: Reconstitute in HO to a concentration of 1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or -20°C for future use.

Amino acid sequence: N/A