GAK Antibody| F40086-0.08ML/F40086-0.4ML

GAK Antibody| F40086-0.08ML/F40086-0.4ML | Gentaur UK, US & Europe Distribution

Background: GAK, a member of the Ser/Thr protein kinase family, associates with cyclin G and CDK5. It appears to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. GAK localizes to the perinuclear area and to the trans-Golgi network. It is also observed on the plasma membrane, probably at focals adhesions. Expression is ubiquitous, wiht highest levels in testis. The protein contains 1 J domain and 1 tensin domain.

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human, Mouse

Predicted Spacies Reactivity: Rat

Application: IHC, WB, ELISA

Application Details: IHC (Paraffin): 1:50-1:100, Western blot: 1:1000

Application Note: Titration of the GAK antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This GAK antibody is available for research use only.

Purity: Purified

Immunogen: A portion of amino acids 15-45 from the human protein was used as the immunogen for this GAK antibody.

Storage: Aliquot the GAK antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A