GAK (Q129) polyclonal Antibody | BS1871

GAK (Q129) polyclonal Antibody | BS1871 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse

Application: IHC

Application Range: IHC: 1:50~1:200

Background: Cyclin D1 accumulates during G1 and associates with Cdk2, Cdk4 and Cdk5. Cyclin E and Cdk2 interact during the G1 to S transition. Cyclin G contains a typical N terminal cyclin box and a carboxy terminal domain sequence homologous to the tyrosine phosphorylation site of the epidermal growth factor receptor) . Cyclin G expression is induced within 3 hours after growth stimulation and remains elevated with no apparent cell cycle dependency. A serine/threonine kinase, designated GAK for cyclin G associated kinase, has been identified. GAK has been shown to bind directly to cyclin G and to co-immunoprecipitate with Cdk5, which also associates with cyclin G.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: GAK (Q129) polyclonal Antibody detects endogenous levels of GAK protein.

Molecular Weight: ~ 143 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Cyclin-G-associated kinase

Immunogen: Synthetic peptide, corresponding to amino acids 101-150 of Human GAK.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: