Galantamine Hydrobromide | B3094

Galantamine is an alkaloid originally isolated from the bulbs and flowers of various Galanthus species. It inhibits acetylcholinesterase with an IC₅₀ of 800 nM. It is a potent allosteric potentiating ligand of human α₃β₄, α₄β₂ and α₆β₄ nicotinic receptors (nAChRs). It is used for the treatment of vascular dementia in Alzheimer’s disease.

Galantamine is an alkaloid originally isolated from the bulbs and flowers of various Galanthus species. It inhibits acetylcholinesterase with an IC₅₀ of 800 nM. It is a potent allosteric potentiating ligand of human α₃β₄, α₄β₂ and α₆β₄ nicotinic receptors (nAChRs). It is used for the treatment of vascular dementia in Alzheimer’s disease.

B3094 | Galantamine Hydrobromide DataSheet

Alternate Name/Synonyms: Galanthamine hydrobromide; Reminyl; (1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetracyclo[8.6.1.01,12.06,17]heptadeca-6(17),7,9,15-tetraen-14-ol;hydrobromide; (4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol Hydrobromide

Appearance: White crystalline solid

Formulation:

CAS Number: 1953-04-4

Structure Available?: TRUE

Peptide sequence:

Salt Form: TRUE

Molecular Formula: C₁₇H₂₂BrNO₃

Molecular Weight: 368.27

Cell-Permeable?: True

Purity: ≥ 98%

Solubilities: ~7 mg/ml in water, ~7 mg/ml in DMSO (may need gentle warming)

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of acetylcholinesterase

MDL Number: MFCD00067672

PubChem CID: 121587

SMILES: CN1CCC23C=CC(CC2OC4=C(C=CC(=C34)C1)OC)O.Br

InChi: InChI=1S/C17H21NO3.BrH/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17;/h3-6,12,14,19H,7-10H2,1-2H3;1H/t12-,14-,17-;/m0./s1

InChi Key: QORVDGQLPPAFRS-XPSHAMGMSA-N